The endocannabinoid system is found in all mammals, and is made up of millions of cannabinoid receptor sites (CB1 and CB2 receptors) located throughout the body. The endocannabinoid system is one of the regulatory systems in the human body, but most people do very little to support the health of this system, because cannabinoids have not been part of the average diet. If you would like to know more about the technical aspects of the endocannabinoid system, you can go here.
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.
In addition, some cannabinoids interact synergistically, producing unique effects that are not found when using them individually. For example, CBD inhibits THC’s psychotropic effects when the two are taken together. However, CBD does this (and produces many other effects) without directly interacting with the cannabinoid receptors. At first, scientists thought there was a third type of CB receptor just for Cannabidiol, but the answer was far more interesting and revealing.
"What is CBD oil" may be your first question, but the real question we have to answer is, "What does CBD oil do?" CBD interacts with the body through the endocannabinoid system (ECS). First discovered in the late 1980's, the endocannabinoid system regulates the body's homeostasis, or general state of balance. Like an acrobat on a highwire, as the environment around us impacts our normal balance, the endocannabinoid system "connects" by mediating our body's reaction to keep us level.
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Food and beverage products containing CBD were introduced in the United States in 2017.[dubious – discuss][46] Hemp seed ingredients which do not naturally contain THC or CBD (but which may be contaminated with trace amounts on the outside during harvesting) were declared by the FDA as GRAS in December 2018. CBD itself has not been declared GRAS, and under U.S. federal law is illegal to sell as a food, dietary supplement, or animal feed.[13] State laws vary considerably as non-medical cannabis and derived products have been legalized in some jurisdictions in the 2010s.
The passage of the 2018 Farm Bill made it legal to sell hemp and hemp products in the U.S. But that doesn't mean that all hemp-derived cannabidiol products are legal. Since cannabidiol has been studied as a new drug, it can't be legally included in foods or dietary supplements. Also, cannabidiol can't be included in products marketed with therapeutic claims. Cannabidiol can only be included in "cosmetic" products and only if it contains less than 0.3% THC. But there are still products labeled as dietary supplements on the market that contain cannabidiol. The amount of cannabidiol contained in these products is not always reported accurately on the product label.
Seizure disorder (epilepsy). A specific cannabidiol product (Epidiolex, GW Pharmaceuticals) has been shown to reduce seizures in adults and children with various conditions that are linked with seizures. This product is a prescription drug for treating seizures caused by Dravet syndrome or Lennox-Gastaut syndrome. It has also been shown to reduce seizures in people with tuberous sclerosis complex, Sturge-Weber syndrome, febrile infection-related epilepsy syndrome (FIRES), and specific genetic disorders that cause epileptic encephalopathy. But it's not approved for treating these other types of seizures.
When taken by mouth: Cannabidiol is POSSIBLY SAFE when taken by mouth or sprayed under the tongue appropriately. Cannabidiol in doses of up to 300 mg daily have been taken by mouth safely for up to 6 months. Higher doses of 1200-1500 mg daily have been taken by mouth safely for up to 4 weeks. A prescription cannabidiol product (Epidiolex) is approved to be taken by mouth in doses of up to 10-20 mg/kg daily. Cannabidiol sprays that are applied under the tongue have been used in doses of 2.5 mg for up to 2 weeks.
Food and beverage products containing CBD were introduced in the United States in 2017.[dubious – discuss][46] Hemp seed ingredients which do not naturally contain THC or CBD (but which may be contaminated with trace amounts on the outside during harvesting) were declared by the FDA as GRAS in December 2018. CBD itself has not been declared GRAS, and under U.S. federal law is illegal to sell as a food, dietary supplement, or animal feed.[13] State laws vary considerably as non-medical cannabis and derived products have been legalized in some jurisdictions in the 2010s.
Until relatively recently (1980s), scientists believed that CBD was a natural precursor to the formation of THC, and since THC was a strictly controlled substance back then (it still is), it only followed that CBD should be equally strictly regulated. However, CBD is actually unrelated to the chemical chain that results in THC. They share some characteristics but are created via different paths. Again, unlike THC, CBD is considered a legal cannabinoid and is safe to consume in any amount and concentration. cbd oil

CBD comes in many forms, including capsules, extracts, honey-infusions, topical ointments and edibles. But because CBD isn’t FDA-regulated, it’s important to be cautious when choosing a product. In fact, ConsumerLab.com found that the amount of CBD in products may vary widely – from 2 mg to 22 mg per dose – and the strength isn’t always accurately disclosed on the label. (The amount of any incidental THC may not be accurately disclosed either).
As of April 2019, CBD extracted from marijuana remains a Schedule I Controlled Substance,[13][71][72][73] and is not approved as a prescription drug, dietary supplement, or allowed for interstate commerce in the United States. CBD derived from hemp (with 0.3% THC or lower) was delisted as a federally scheduled substance by the 2018 Farm Bill. FDA regulations still apply: hemp CBD is legal to sell as a cosmetics ingredient, but despite a common misconception, because it is an active ingredient in an FDA-approved drug, cannot be sold under federal law as an ingredient in food, dietary supplements, or animal food.[74] It is a common misconception that the legal ability to sell hemp (which may contain CBD) makes CBD legal.[74]

^ Jump up to: a b c Devinsky, Orrin; Cilio, Maria Roberta; Cross, Helen; Fernandez-Ruiz, Javier; French, Jacqueline; Hill, Charlotte; Katz, Russell; Di Marzo, Vincenzo; Jutras-Aswad, Didier; Notcutt, William George; Martinez-Orgado, Jose; Robson, Philip J.; Rohrback, Brian G.; Thiele, Elizabeth; Whalley, Benjamin; Friedman, Daniel (May 22, 2014). "Cannabidiol: Pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders". Epilepsia. 55 (6): 791–802. doi:10.1111/epi.12631. PMC 4707667. PMID 24854329.


Cannabis – A type of flowering plant that includes three distinct variations: Cannabis ruderalis, Cannabis indica, and Cannabis sativa. Cannabis has a wide range of industrial and medical applications. It has been used since antiquity for its sturdy fiber, for oils, and for medicinal purposes. However, it has also been used as a recreational drug, a fact that renders the cultivation of cannabis strictly regulated because of some variations including high concentrations of THC.
CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. This information may not fit your specific health circumstances. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. You should always speak with your doctor or health care professional before you start, stop, or change any prescribed part of your health care plan or treatment and to determine what course of therapy is right for you.

As of April 2019, CBD extracted from marijuana remains a Schedule I Controlled Substance,[13][71][72][73] and is not approved as a prescription drug, dietary supplement, or allowed for interstate commerce in the United States. CBD derived from hemp (with 0.3% THC or lower) was delisted as a federally scheduled substance by the 2018 Farm Bill. FDA regulations still apply: hemp CBD is legal to sell as a cosmetics ingredient, but despite a common misconception, because it is an active ingredient in an FDA-approved drug, cannot be sold under federal law as an ingredient in food, dietary supplements, or animal food.[74] It is a common misconception that the legal ability to sell hemp (which may contain CBD) makes CBD legal.[74]


With that being said, one is not necessarily better than the other. CBD can be much more welcoming for those who do not want the potential high that comes with THC. THC may also offer more than just a high, with studies suggesting that it may possess health benefits of its own. More recently, evidence has suggested that THC and CBD can work together through what is known as the “entourage effect”. Taken together, CBD, THC, and the other compounds found in cannabis become more than the sum of their parts, amplifying their effects and working in synergy to support better health and well-being. It’s fine if you want just CBD on its own, but pairing your CBD with some THC may actually be good for you and give you whole plant benefits.
Laboratory evidence indicated that cannabidiol may reduce THC clearance, increasing plasma concentrations which may raise THC availability to receptors and enhance its effect in a dose-dependent manner.[20][21] In vitro, cannabidiol inhibited receptors affecting the activity of voltage-dependent sodium and potassium channels, which may affect neural activity.[22] A small clinical trial reported that CBD partially inhibited the CYP2C-catalyzed hydroxylation of THC to 11-OH-THC.[23] Little is known about potential drug interactions, but CBD-mediates a decrease in clobazam metabolism.[24]
Answering the question 'what is CBD oil' would be incomplete without mentioning the many CBD oil benefits. By positively affecting the endocannabinoid system, CBD promotes overall health and wellness in people young and old. You can even find CBD for pets that is specifically formulated to safely allow your pets to experience the natural benefits of CBD.
To make this more concrete, let’s use an example here. This is a high-CBD hemp oil product made from industrial hemp. It has a concentration of CBD between 18% and 24%. This means that it has 18%–24% parts CBD dissolved in the actual oil, which is composed by other substances. So 18%–24% is pure CBD, and the rest are hemp oil extracts and other fatty acid substances.
In the United States, the cannabidiol drug Epidiolex was approved by the Food and Drug Administration in 2018 for treatment of two epilepsy disorders.[12] Since cannabis is a Schedule I controlled substance in the United States, other CBD formulations remain illegal to prescribe for medical use or to use as an ingredient in foods or dietary supplements.[13]
A type of anxiety marked by fear in some or all social settings (social anxiety disorder). Some early research shows that taking cannabidiol 300 mg daily does not improve anxiety during public speaking in people with social anxiety disorder. However, other early research in people with social anxiety disorder suggests that taking a higher dose (400-600 mg) may improve anxiety associated with public speaking or medical imaging testing. Also, some research in people who do not have social anxiety disorder shows that taking cannabidiol 300 mg might reduce anxiety during public speaking. cbd oil
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