Receptors for cannabinoids are found in the digestive, reproductive, nervous, and immune systems. Because cannabinoids interact with almost every system in our bodies, they’re often touted as a cure-all. While they’re not truly able to heal everything, they do regulate neurotransmitter function, inflammation, mitochondrial function, and metabolism.
Cannabis and alcohol both increase alpha and theta sleep and decrease delta sleep. Cannabis and alcohol inhibit delta sleep needed for the night time brain housekeeping duties and increase luteinizing hormone so core body temperature does not drop for brain cells to shrink for 60% more space between brain cells for the cerebral spinal fluid to wash out toxins. Since pot inhibits delta sleep, it also inhibits growth hormone and also dehydrates you, so klotho is reduced. Cannabis causes kidney stones by reduced klotho. Klotho is anti tumor, anti dementia, inhibits arteriosclerosis, osteoporosis, and skin atrophy, so since cannabis inhibits klotho, aging is increased. Cannibis decreases sex hormones, increases stress hormones, impairs fertility, inhibits copulation, reduces oxytocin-the love and protection hormone.
It is also beneficial to oxygenate the body. In 1931 Dr. Otto Warburg won his first Nobel Prize for proving cancer is caused by a lack of oxygen respiration in cells. He stated in an article titled The Prime Cause and Prevention of Cancer that "the cause of cancer is no longer a mystery, we know it occurs whenever any cell is denied 60% of its oxygen requirements." 
One classic use is in soaps. Hemp oil is also used in paints and lubricants, and as a body care product. It may be rubbed directly onto the skin to treat cracked, dry skin, or it can be blended into body oils, body creams, and other personal care products. Some people also use it as a dietary supplement, taking advantage of the high concentrations of essential fatty acids in unrefined hemp oil and using the oil as a dressing or garnish to improve nutrition.
Feminized seeds, which guarantee 99.9% female crops, are more popular than organic regular seeds as no male plants must be removed. Intersex plants are semi-rare, but stress can turn a female into a “hermie”, with both buds and pollen sacs developing. Cannabis cultivators will cull these plants like males to prevent pollination. Sinsemilla or seed-free flower is the benchmark for high-grade bud.
^ Nadulski T, Pragst F, Weinberg G, Roser P, Schnelle M, Fronk EM, Stadelmann AM (December 2005). "Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extract". Ther Drug Monit. 27 (6): 799–810. doi:10.1097/01.ftd.0000177223.19294.5c. PMID 16306858.
As for phytocannabinoid-rich hemp oil, due to the presence of the hemp plant’s cannabinoids there are many additional uses and benefits with practically zero side effects. The most common use of this type of hemp oil is for chronic pain management, but many people also use it to treat some symptoms of cancer, among other diseases and conditions. Even the Food and Drug Administration recently approved a new CBD-based prescription medication.
Not personally, but a close friend who had chronic insomnia, tried and is using off and on a 1:1 tincture under their tongue at night before bed. The first night they took it they dreampt for the first time in many years and started getting better quality, deeper restorative sleep and even a little longer sleep time. Was not a complete solution but it helped them.
There's also the question of CBD's legality – something that's a lot grayer than the black-and-white picture most companies paint. The U.S. Drug Enforcement Administration considers CBD, like all cannabinoids, a schedule 1 drug. That means it's just as illegal as heroin and ecstasy. Meanwhile, hemp – a variety of the cannabis plant regulated by the U.S. Department of Agriculture – is legal , so long as its THC content is negligibly low. But because the agriculture department doesn't test for CBD – only THC – in hemp, more companies are getting away with selling products they say contain CBD, says Sara Jane Ward, an assistant professor of pharmacology at the Temple University Lewis Katz School of Medicine who's been studying CBD in rodent models for more than 10 years. Needless to say, the legality of CBD is "very confusing and very gray," she says.
In this review, the effects of cannabinoids in the regulation of the following endocrine systems are discussed: the hypothalamic-pituitary-gonadal axis and hypothalamic-pituitary-adrenal cortex axis. Cannabis users have reduced levels of gonadotropins, reduced prolactin and growth hormone. Cannabis affects corticotropin-releasing hormone-, thyrotropin-releasing hormone-, vasopressin-, and oxytocin-expressing neurons. Therefore, our findings reveal a mechanism of rapid glucocorticoid feedback inhibition of hypothalamic hormone secretion via endocannabinoid release in the paraventricular nucleus of the hypothalamus and provide a link between the actions of glucocorticoids and cannabinoids in the hypothalamus that regulate stress and energy homeostasis. Glucocorticoid negative feedback in the brain controls stress, feeding, and neural-immune interactions by regulating the hypothalamic-pituitary-adrenal axis. Cannabis increases dopamine which decreases prolactin. Cannabis decreases oxytocin, thyroid hormone and growth hormone, and disrupts the hypothalamic-pituitary-adrenal axis. Cannabinoids suppress fertility via reducing hypothalamic gonadotropin- releasing hormone output. γ-Aminobutyric acid (GABA)(A) receptor (GABA(A)-R)-mediated transmission is a major input to gonadotropin releasing hormone cells that can be excitatory. Cannabinoids act via inhibiting GABAergic input. Cannabis disregulates the hypothalamic-pituitary-adrenal axis circadian rhythm. Cannabis decreases serum concentrations of pituitary gonadotropins. Cannabis raises cortisol and ACTH which increases cortisol which uses up progesterone reducing testosterone and estrogen. Cannabis lowers testosterone in men by inhibiting testosterone secretion and impairs fertility in males through alteration in the testicular endocannabinoid system. Cannabis suppresses copulatory behavior even when testosterone levels are maintained. It decreases sperm concentration, causes defective sperm function or alteration of sperm morphology. Endocannabinoids control male reproduction acting at central and local level via cannabinoid receptors. The cannabinoid receptor CB1 has been characterized in the testis, in somatic and germ cells of mammalian and non-mammalian animal models, and its activity related to Leydig cell differentiation, steroidogenesis, spermiogenesis, sperm quality, and maturation. Testicular degeneration and necrosis is induced by chronic administration of cannabis. In both ovulating and menopausal women, cannabis can alter pituitary gonadotropin release and alter metabolism or target tissue response to gonadal steroids, leading to reduced estrogen and progesterone production and anovulatory menstrual cycles. Cannabis presents abnormal longer ovulatory cycle lengths in females. Cannabis suppresses luteinizing hormone when sex hormones are initially high, but, chronic cannabis lowers progesterone and testosterone in men, and lowers estrogen and progesterone in women, so luteinizing hormone significantly increases which raises night time core temperature for disrupted sleep. Cannabis increases hypothalamic nitric oxide which inhibits oxytocin. Cannabis is detrimental for lactating moms. Cannabis decreases maternal care, decreases aggressive instinctual behaviors for protection of young, suppresses maternal anxiolysis, decreases plasma oxytocin levels and milk consumption and decreases activation of oxytocinergic neurons in hypothalamic nuclei. Changes in the behavioral responses of lactating mothers treated with cannabis can be related to disruption in the neuroendocrine control of oxytocin secretion. Cannabis causes impairment of glucocorticoid feedback which either enhances or decreases performance on various tasks. Cannibis can cause a decrease in thyroid which negatively affects cerebellar development and motor performance involved in adult brain function. It induces consistent behavioral changes in adults, leading to severe anxiety and morphological changes in the hippocampus, however, it shows improvements for schizophrenia: improvement in cognitive function and reduction of antipsychotic-side. Cannabis and Δ(9) -THC are anticonvulsant in most animal models but can be proconvulsant in some healthy animals. The simultaneous rapid stimulation of nitric oxide and endocannabinoid synthesis by glucocorticoids has important implications for the impact of stress on the brain as well as on neural-immune interactions in the hypothalamus. Cannabis has implications for psychosis. There are blunted psychotomimetic and amnestic effects with cannabis. Lithium increases oxytocin and helps in cannabis withdrawal, and pregnenolone/progesterone help in cannabis withdrawal as estrogen generally increases and progesterone decreases sensitivity to marijuana.

And CBD has over 40 different ailments that is supports, as found at www.ProjectCBD.org/conditions.. and it also has been a great preventative solution for many people. This is NOT a prescription. This is an all natural plant with some all natural herbs. If you want to break open the capsules and stick them in your favorite smoothie, that will work also.


What about cannabis oil? Well, unlike both CBD oil and hemp oil, cannabis oil does contain THC and it is psychoactive. Cannabis oil comes from the Cannabis sativa plant that’s bred for its trichomes. These trichomes are tiny, hair-like crystals that cover the leaves and buds of the cannabis plant. Trichomes produce the hundreds of known cannabinoids that can be found in marijuana.
NuLeaf Naturals CBD oil tinctures are all full spectrum; it is 100% organic and never made with herbicides, pesticides, or chemical fertilizers. The brand offers a full spectrum pet CBD oil tincture, as well. NuLeaf Naturals offers free shipping to all 50 states; the brand’s products are also sold in more than 1,000 retail locations across the country.
Correct, I am not a doctor, and this is not to be interpreted as medical advice. I would recommend you talk to a licensed medical professional about all of this. I'm not sure what the product is so I can't recommend guidelines for taking it. If you're referring to my product, NatureCBD, as a general guideline, start with 2-3 capsules a day and not exceeding 5 tablets in 24 hours. I have personally seen no contraindications for CBD and blood pressure meds.

Online retailers: Most CBD oils are sold through online retailers. These establishments tend to have the widest product range, and many offer free doorstep delivery. Online retailers also frequently post product reviews, allowing buyers to compare different oils based on customer experiences to determine which is best for them. These reviews can also be used to evaluate the retailer based on customer service, delivery, and product quality.
Carol, thanks for your long and detailed post, and the links. In your paragraph where you reference various effects, you write “cannabis” several times. There are several components of “cannabis”, THC is the more psychoactive component – and current varieties have been bred/engineered to have ever increasing concentrations of this. CBD is another component, which has different and in some cases opposing effects vs. THC. Are the statements you made about effects of “cannabis”, do they center on THC, consumption/use of the whole plant, or have they broken out a purified CBD product and tested the impacts of just that component. Earnest question.
To my understanding, neither CBD nor THC are effective for “severe” pain; rather, they work better for mild to moderate chronic pain. Often, with severe pain, the dosage of opiates can be decreased with concomitant use of medical cannabis or CBD and that decrease in dose makes their use safer. Concurrent use of THC does increase the analgesic effect of CBD, but it also adds the “high” which some people do not want as a side effect.
Sub-lingual CBD drops have helped me enormously with sleeping and with radiation damage pain. I have a cancer that spread from the pelvic area to my sacrum and sciatic nerve and whilst the chemo and radiotherapy saved my life I have been taking MST (morphine derivative) for nerve pain ever since. My tumours are presently all quiet and last March I decided I wanted to stop taking the pain relief drugs, fearing dementia. CBD oil was recommended by my son who has arthritis and, for me, it really works. It’s so good to read an article that isn’t put out by a CBD sales site – I wish it could be properly prescribed and regulated (I’m in the UK) in order to have confidence with purity and dosage.
An actual long term study, Ganja in Jamaica: A Medical Anthropological Study of Chronic Marijuana Use, which was published in the Journal of the American Medical Association in 1975, showed zero concerns with addiction, even after patients who had used cannabis for decades had stopped. The 1980 study Cannabis in Costa Rica: A Study in Chronic Marijuana Use backed this up. Most interestingly, studies like this are not finding any addictive potential with CBD even in the presence of THC!
At least one benefit of CBD is well-supported by science: It can be effective in treating children with rare, genetic seizure disorders. Adults, children and even animals with epilepsy have been shown to benefit from the chemical too, the World Health Organization reports. There's also some evidence that CBD can help with anxiety, says Dr. Robert Carson, an assistant professor of neurology and pediatrics at Vanderbilt University who focuses on children with epilepsy. "In children, especially those with autism spectrum disorders, this may manifest as improved interactions with others," he says. Other preliminary research shows CBD holds promise for conditions including Alzheimer's disease, cancer, psychosis and Parkinson's disease – and is pretty much impossible to abuse or become addicted to, WHO says.
CBD oil is most readily available as a tincture. This can be taken by applying a few drops under your tongue, holding in your mouth for a few moments so it can be absorbed, before swallowing. It can also be added to water or smoothies. A spray form is available (simply spritz under your tongue), as are capsules, creams that can be applied topically, and e-liquid for vape pens.

Quick question about CBD oil. I am in my late 30s and have been racing endurance MTB for 20ish years. The past 5 years I have developed TERRIBLE hamstring cramping after an hour, where I dont even want to ride my bike anymore. I know its not a cure all, but im curious if dosing with CBD before a 6 hour race will help inflammation and possibly help reduce cramping. I hate it and its sad to not be able to ride too much just being afraid to cramp. I mean cramp as in last time it happened I spent the night in the ER waiting for the muscles to relax after 3 hours of solid cramping..wanting to pass out cramping. No fun. Thanks for any insight
There are a few important matters to discuss regarding CBD hemp oil concentrates. First, it’s important to place the oil under your tongue because the mouth consists of capillary glands that absorb the oil. This allows the CBD to enter your system quickly. By the time you swallow the oil, a significant amount of CBD will have already been absorbed.
All cannabis oil packaging must also state the percentage of THC and CBD in the oil (so you know how potent and psychotropic it is before you use it). Just like strains of dried cannabis, oils can have stronger concentrations of CBD, THC, or be more balanced, and thus create very different experiences. Not all oils are created equal – so reading the packaging is crucial for your first time. 
Speaking of dosage, in most clinical trials, you’ll see CBD dosing ranges from 10-800 mg of CBD per day (although to treat schizophrenia, I’ve seen doses as high as 1,300mg). But as with everything from whey protein to creatine to magnesium, everyone is different and you’ll likely need to experiment with a dosage range that works for you. The CBD capsules I personally use contain 10mg in one capsule, but based on the absorption (an important variable which you’re going to learn about next), I need to use far less CBD, about 1/10 the amount, compared to other CBD tinctures, extracts and capsules I’ve tried.
These creams are also used by those suffering from arthritic symptoms. According to this study, CBD could relieve painful arthritic symptoms without the negative side effects that sometimes accompany the use of pharmaceutical drugs. The study reports that by using a topical cannabis oil cream, the metabolic system is bypassed thereby increasing absorption, assimilation, and efficiency of CBD.
Your pancreas secretes the hormones glucagon and insulin to regulate blood sugar by signaling your liver to break down fat into sugar (glucagon) or to store sugar as fat (insulin). These hormones work as a pair to maintain homeostasis, and they stimulate the release of each other through a complex feedback mechanism. While THC primarily increases glucagon and blood sugar, CBD lowers insulin levels, and it is this CBD action that helps to explain why marijuana users tend to eat more calories but do not gain any extra weight, have less obesity and have lower rates of type II diabetes than non-users, and is also why some diabetics find that marijuana makes it easier to manage their blood sugar.
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Unfortunately due to the disappointing and down right inaccurate position of the federal government in classifying Cannabis as a schedule one drug, most research institutions risk federal funding if they conduct real research on Cannabis. This has dramatically limited the potential for real research by real scientists to be conducted. That research is critical to better understanding the multitude of therapeutic effects of the various chemical constituents found in Cannabis.
Sub-lingual CBD drops have helped me enormously with sleeping and with radiation damage pain. I have a cancer that spread from the pelvic area to my sacrum and sciatic nerve and whilst the chemo and radiotherapy saved my life I have been taking MST (morphine derivative) for nerve pain ever since. My tumours are presently all quiet and last March I decided I wanted to stop taking the pain relief drugs, fearing dementia. CBD oil was recommended by my son who has arthritis and, for me, it really works. It’s so good to read an article that isn’t put out by a CBD sales site – I wish it could be properly prescribed and regulated (I’m in the UK) in order to have confidence with purity and dosage.
I have crohns dibeates 2 stage kidney failure I take 6000 mg of chemicals a day when I get a flair l might lose a lot of blood I've had fistula surgery once darn mean killed me 2 more just gut surgerys little bit of gut removed I tease my gut doctor he schoold just put in a zipper any way I'm looking for something natural to try for pain also where I live if you get caught automatic life so the delima begins how much would any one suggest starting out with thanks for your time also compared to most of the folks mine seems like a minor problem on this site but I would appreciate some advice I hope all you folks have good lives and remember god always loves you even though sometimes you think he may have forgotten you
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