Cannabidiol, more commonly known as CBD, is one of the many identified cannabinoid molecules found in Cannabis plants. Like all cannabinoid molecules, it interacts with the endocannabinoid system in the human body. But because CBD isn’t psychoactive, it doesn’t produce the “high” commonly associated with its more famous cannabinoid cousin, THC. That means that CBD, which is often derived from hemp, or male cannabis plants, doesn’t produce the high that cannabis products are often associated with.
CBD can, however, affect the salivary gland and result in dry mouth. Whether or not dry mouth could be considered a side effect depends on the person who experiences it. Remember, side effects are usually negative and unwanted in some way. But dry mouth may be a small price to pay for a reduction in pain or psychosis. Especially if side effects from other medications are almost as bad as the disease itself.
As you’ve probably already heard, the hemp plant itself is a highly useful plant, and every part of it has been used to make a wide variety of products, including biofuel and medicine. Biofuel made from hemp seeds is far less expensive and more effective than ethanol derived from corn. If there weren’t so many federal restrictions, growing hemp would highly benefit any agricultural state, but unfortunately most states must pay an absurdly high premium to import hemp seeds. And of course, as you’re probably aware, both THC and CBD seem to be immersed in a constant struggle of medical legality that I simply don’t have the time to address in this post.
In order to remove unwanted elements such as fats or waxes, CBD oil is subjected to a process called ‘Winterization’. Refined cannabidiol oil is stirred with alcohol and deep-frozen overnight.  A Butcher funnel or a piece of paper is then used to filter the fats out. Finally, the extracted oil is heated to the boiling point of alcohol so the alcohol evaporates.
Also, controlling dosing can be particularly difficult with vape pens. How much CBD you absorb depends on how hard and long you inhale, Earleywine says. In addition, labels on vaping devices can be especially confusing, he says. “You might get a vape oil that says it has 1,000 mg of CBD, but it’s not clear if that’s how much is in the whole bottle or in each inhalation. It can be hard to guess what your dosage really is under some of those situations.”
If medical marijuana is illegal in a given state, THC levels determine whether a CBD product is illicit or not. In most places, the limit is extremely low. We’re talking under 1 percent THC, with some states opting for a cap as low as 0.3 percent. In this case, the only source that would work is hemp, and CBD products will, therefore, be hemp-derived.
It is important to note that NIDA’s mission is focused on drug abuse; studies related to the therapeutic effects of CBD in other areas would be funded by the Institute or Center responsible for that program area. For example, studies related to epilepsy will likely be funded by the National Institute of Neurological Disorders and Stroke or by the Eunice Kennedy Shriver National Institute of Child Health and Human Development, while studies related to schizophrenia will likely be funded by the National Institute on Mental Health.
Thank you for your questions. Marijuana and hemp are two extremely different strains of the same cannabis sativa plant that have been bred over thousands of years to have entirely different purposes. (Hemp is not the male version of the marijuana plant.) They both contain CBD. Hemp only contains CBD whereas marijuana contains CBD and perhaps a hundred or so other chemicals with a variety of functions, such as THC, the molecule that makes people “high”. Any medicine can have different effects on different people. For example, Benadryl makes some people sleepy yet can make others wide-awake. So, it is not inconsistent for a particular medicine to cause a symptom in one person and to help alleviate it in another. So while many people experience relaxation with CBD, so people do experience the “paradoxical” effect of irritability.
Starting with larger doses would be good to help patients get off addictive and dangerous pain medications like Morphine or Vicodin.  When people using those type of medications start the cannabis oil treatment, they can a lot of times, cut their pain medications by as much as half. It might also be good to start with larger doses if the cancer is in the late stages.  Most importantly though you always want to make sure you stay within your "comfort zone" when taking the cannabis oil.  Everyone is different, some people can take more than others. So make sure that the dose you take is right for you.
It’s also nearly impossible to overdose on CBD. Kind of like water, dark chocolate, and steamed kale, it has an unusually low level of toxicity. In the last 6,000 years, CBD hasn’t killed anyone via overdose, which is particularly impressive when you compare it to non-steroidal anti-inflammatory drugs (NSAIDs), such as ibuprofen, Advil and Tylenol, which can wreak havoc on your gut lining, liver and kidneys. Or aspirin (salicylic acid) which kills over 1,000 people every year. Or alcohol, which kills over 110,000 people a year. No one’s ever died from CBD.
^ Jump up to: a b Resstel LB, Tavares RF, Lisboa SF, Joca SR, Corrêa FM, Guimarães FS (January 2009). "5-HT1A receptors are involved in the cannabidiol-induced attenuation of behavioural and cardiovascular responses to acute restraint stress in rats". British Journal of Pharmacology. 156 (1): 181–8. doi:10.1111/j.1476-5381.2008.00046.x. PMC 2697769. PMID 19133999.
CBD is an anticonvulsant, and some other compounds in the plant, including THC and cannabidivarin, may be too. There is good evidence from clinical trials in the US and Europe that pharmaceutical preparations of CBD can treat two severe forms of childhood epilepsy known as Dravet syndrome and Lennox-Gastaut syndrome. Both forms of epilepsy often fail to improve with existing epilepsy drugs. CBD is generally considered safe, but some trials have reported side effects including dry mouth, lightheadedness and altered liver enzyme activity.
Hi, I have foot pain especially feel sever pain while I wake up from bed at morning and stand up on my foot feel may be I will disable to stand up any more for this pain besides, have sever foot inflammation all day long excepting sleeping mode otherwise it is giving me a hell of pain since 2012 to till now. Please suggest me if I use your Premium Hemp Seed Oil and or Capsule will my pain heal and how to use oil or capsule?
So Herrera, who's experienced her own share of pain due to a shoulder injury followed by a bout of Lyme disease, went to a local herb shop and bought a vial of the oil, which, by some definitions, is legal in all states if it doesn't contain more than 0.3 percent THC – the psychoactive component of cannabis. She began putting seven to nine drops under her tongue first thing most mornings – and was startled by the results. "It's changed my pain level, my anxiety level and my stress level," says Herrera, who already practiced yoga, meditated regularly, ate a healthy diet and tried conventional medical treatments for pain and mobility. "It was shocking," she says, because she thought her patients' reports were due to the placebo effect. "Right now," she adds, "I feel pretty amazing."

HI Leslee, there are so many oils out there and I always talk about absorption when I talk about this oil. What is important is how much you absorb and if the hemp has a delivery vehicle that can get past the blood-brain barrier. This is so important, or you are taking the oil and peeing it out… I mean you will get some of the benefits, which some benefits are great, right? But I always want the most for my investment. We all have to consider three factors when making a decision around our health investments 1-time, 2-energy and 3- finances. TIme in the sense that it will take time for the body to assimilate and adjust, I’d rather your time be spent with an oil that is potent and absorbable. 2. It takes energy to commit and be dedicated to caring for your body, which means taking the oil everyday… then lastly 3. Money, I would rather someone invest in a product that is going to move the needle so to speak, quickly rather than it taking weeks and not having someone find or feel the effects, then saying, “OH that CBD HEMP STUFF doesn’t work…” 🙁 Make sense?


If medical marijuana is illegal in a given state, THC levels determine whether a CBD product is illicit or not. In most places, the limit is extremely low. We’re talking under 1 percent THC, with some states opting for a cap as low as 0.3 percent. In this case, the only source that would work is hemp, and CBD products will, therefore, be hemp-derived.
I am in Santiago, Chile and have bought Cannabis oil here. It is my first time to try it. I am awaiting shipment from U.S. of CBD oil products. I am using the oil to ally my rather constant low level anxiety that sometimes goes near panic as well as chronic sleeplessness. I have been dealing with this challenge for many years without resorting to standard “Harmapheuticals”. It is my hope the oils will calm me and bring me sleep. I have been trying these local oils for past four days without too much in the way of calming effects. I am taking around 30ml of the oil without real positive results. Do you suppose I may have to go to dosage over 100ml a day to get results? I realize you can not give medical advice nor am I asking for it–but if you can give me general directions it would be very helpful. Thanks, Jack in Chile.

From what I understand, CBD derived from the hemp plant does not have the side effects mentioned above, other than possibly to help reduce the amount of Coumadin/Warfarin needed – either way, a patient on this drug needs to be monitored and regularly tested anyway with their doctor. CBD derived from the marijuana plant (will contain THC) may have them, I do not know, maybe that’s why you mention them. One of the many reasons people take Hemp CBD is that it does NOT have the side effects! People take the Hemp version to help with feelings of fatigue, irritability & anxiousness, it does cause it! It helps to bring the body into balance.


Cannabis has been around for thousands of years and is believed to have originated in South or Central Asia. The two main species of cannabis are Cannabis sativa and Cannabis indica. Both Cannabis sativa and indica contain varying amounts of psychoactive and nonpsychoactive components. Cannabis sativa is more commonly known for its stimulatory, mental effects while Cannabis indica is more known for its relaxing, body-calming effects.

The most appropriate delivery system for CBD-rich cannabis is one that provides an optimal dose for a desired duration with few unwanted side effects. CBD-rich cannabis flower varietals for smoking or vaping are available in many medical marijuana dispensaries, but most CBD patients prefer non-inhalable products made with cannabis oil concentrates. Although banned by federal law, measurable doses of potent CBD-rich cannabis remedies are available in many non-smokable forms and can be utilized in various ways. The time of onset and duration of effect vary depending on the method of administration. CBD-rich cannabis oil products can be taken sublingually, orally (as edibles, lozenges, beverages, tinctures, and gel caps), or applied topically. Concentrated cannabis oil extracts can also be heated and inhaled with a vape pen. Inhalation is good for treating acute symptoms that require immediate attention; the effects can be felt within a minute or two and typically last for a couple of hours. The effects of orally administered CBD-rich cannabis oil can last for four hours or more, but the onset of effects is much slower (30-90 minutes) than inhalation.


At the federal level, CBD is classified as a Schedule 1 drug in the U.S. because it is one of the many cannabinoids present in marijuana. However, CBD products that are derived from industrial hemp are being sold legally, but only under the strict regulations of the 2018 Farm Bill. Under the new bill, legal hemp-derived CBD products must contain less than 0.3 percent THC and can only come from licensed hemp growers.
Mr. Chairman, Ms. Chairwoman, and Members of the Senate Drug Caucus, thank you for inviting the National Institute on Drug Abuse (NIDA), a component of the National Institutes of Health (NIH), to participate in this hearing to share what we know about the biology and the potential therapeutic effects of cannabidiol (CBD), one of the main active chemical compounds found in marijuana. In light of the rapidly evolving interest in the potential use of marijuana and its derivative compounds for medical purposes, it is important to take stock of what we know and do not know about the therapeutic potential of CBD.
A number of studies over the last two decades or more have reported that CBD has anti-seizure activity, reducing the severity of seizures in animal models.vi,vii In addition, there have been a number of case studies and anecdotal reports suggesting that CBD may be effective in treating children with drug-resistant epilepsy.viii,ix,x However, there have only been a few small randomized clinical trials examining the efficacy of CBD as a treatment for epilepsy; the total number of subjects enrolled in these studies was 48. Three of the four studies reported positive results, including decreased frequency of seizures. However, the studies suffered from significant design flaws, including failure to fully quantify baseline seizure frequency, inadequate statistical analysis, and a lack of sufficient detail to adequately evaluate and interpret the findings.viii Therefore, the currently available information is insufficient to draw firm conclusions regarding the efficacy of CBD as a treatment for epilepsy; a recent Cochrane review concluded, there is a need for “a series of properly designed, high quality, and adequately powered trials.”xi

CBD E-Liquid/Vape Cartridges: Vaping is excellent for people looking for an immediate response, as inhalation is the fastest way to deliver CBDs to your brain and body. To use vape simply exhale gently the air from your lungs then inhale through the mouthpiece slowly for 3 seconds. Then fill your lungs the rest of the way with additional breath and hold for a few seconds, exhaling when ready. There are pre-filled, cost-effective vape pens and cartridges available as well as more expensive vaporizers that you can refill with CBD-infused e-liquid.

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