This is where it gets important: Due to THC’s psychoactive qualities, it is known to provide a high that can be either euphoric or accompanied by paranoia and other negative effects, depending upon the strain and user. While THC is frequently used for those suffering from chronic pain, mood disorders, and other medical ailments, its effects can be difficult to predict, and – sometimes – unpleasant.
At least one benefit of CBD is well-supported by science: It can be effective in treating children with rare, genetic seizure disorders. Adults, children and even animals with epilepsy have been shown to benefit from the chemical too, the World Health Organization reports. There's also some evidence that CBD can help with anxiety, says Dr. Robert Carson, an assistant professor of neurology and pediatrics at Vanderbilt University who focuses on children with epilepsy. "In children, especially those with autism spectrum disorders, this may manifest as improved interactions with others," he says. Other preliminary research shows CBD holds promise for conditions including Alzheimer's disease, cancer, psychosis and Parkinson's disease – and is pretty much impossible to abuse or become addicted to, WHO says.
When taken to relief the symptoms of epilepsy, CBD is typically administered orally. Researchers have found that this same method of dosing may be effective in using CBD to treat social anxiety disorder, generalized anxiety disorder, and related conditions. Evidence also suggests that this cannabinoid could be helpful in treating the symptoms of obsessive compulsive disorder.
What’s the best type of CBD to use? Scientists recently discovered that broad-spectrum CBD extracts (from cannabis or hemp plants) are much more effective than so-called “pure” CBD isolates. Researchers think broad-spectrum extracts work better because they contain a variety of molecules that are similar in size and shape to CBD — that all work synergistically together.
Though very rare, some people report side effects when using hemp oil. These side effects include low blood pressure, dry mouth, slowed thoughts, lightheadedness, and sedation. Animal studies have not found any toxicity issues with using CBD. In fact, a study in 2006 found that "the available clinical data suggest that CBD can be safely administered over a wide dose range." As always, because there aren't long-term safety studies, you should always check with your health care provider before starting hemp oil.
Industrial hemp naturally contains very low levels of THC and high levels of CBD. It is legal to purchase CBD oil that comes from the hemp plant because it contains less than 0.3 percent THC. This is good news for consumers who are looking to purchase CBD oil legally and for farmers who can now profit from hemp. In fact, hemp is much easier to grow than marijuana, as it requires less water, no pesticides and minimal care — plus it’s adaptable to most climates.
Remember, the psychological discomfort you’re feeling will pass. Take deep full breaths in through your nose and out through your mouth and just rest a while. Find a warm, comfortable space to lie or sit and try to centre yourself, relaxing music can help. Most symptoms will dissipate within around ten minutes to several hours, depending on dosage – with no lasting effects beyond a little grogginess. Given time these feelings will eventually pass.
Cannabidiol may cause some people to be agitated, irritable, or display other abnormal behaviors. It may also cause some people to have suicidal thoughts and tendencies or to become more depressed. Also tell your doctor if you or your child have sudden or strong feelings, such as feeling nervous, angry, restless, violent, or scared. If you or your caregiver notice any of these side effects, tell your doctor right away.
Cannabidiol has been found to act as an antagonist of GPR55, a G protein-coupled receptor and putative cannabinoid receptor that is expressed in the caudate nucleus and putamen in the brain. It has also been found to act as an inverse agonist of GPR3, GPR6, and GPR12. Although currently classified as orphan receptors, these receptors are most closely related phylogenetically to the cannabinoid receptors. In addition to orphan receptors, CBD has been shown to act as a serotonin 5-HT1A receptor partial agonist, and this action may be involved in its antidepressant, anxiolytic, and neuroprotective effects. It is an allosteric modulator of the μ- and δ-opioid receptors as well. The pharmacological effects of CBD have additionally been attributed to PPARγ agonism and intracellular calcium release.
Some people require very small doses, while some still will feel nothing after a large dose. People also have different reactions to the various methods of use. It may take time to find the proper dosage and delivery method of CBD products to find the needed relief, so be patient. Some effects may be felt immediately, while others take a while to “build up” (particularly when looking for relief from epilepsy).
Some individuals have been found to have mutations on the CNR1 gene, which is responsible for coding the CB1 receptor (a type of receptor in cells throughout your body that interacts with cannabinoids). Issues with the CNR1 gene can ultimately result in a poorly functioning endocannabinoid system, which is an important variable when figuring out how to use CBD oil.